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Linda-S

Synthetic Oxytocin

Dosage Form: Injection
Pack Size: 20 X 1 ml
Composition:

Each ml of Linda-S contains: Synthetic Oxyocin USP 5 IU.

Each ml of Linda-DS contains: Synthetic Oxytocin USP 10 IU



Allygest
Description:

The active substance of LINDA-S is synthetically prepared oxytocin, which is identical to the natural occurring hormone from the posterior pituitary gland. Oxytocin causes contractions of the uterus, thus mimicking contractions of normal, spontaneous labour and transiently impeding uterine blood flow. Amplitude and duration of uterine contractions are increased, leading to dilation and effacement of the cervix. Oxytocin also stimulates the smooth muscle associated with the secretory epithelium of the lactating breast causing ejection of milk out of the mammary ductular system but having no direct effect on milk secretion. 

Linda-S has only minimal cardiovascular and antidiuretic properties. Therefore, it can safely be administered to patients in whom a (further) increase in a blood pressure must be avoided, as in the case of hypertension, toxaemia, (pre-) eclampsia, solution placentae and uraemia. 




Indications:

Induction of labour, stimulation of uterine contractions.

Post delivery period, for the prevention or treatment of secondary haemorrhage and adherent placenta.

To stimulate lactation, only it advised by the registered Gynaecologist/Physician.

Treatment of incomplete abortion to obtain more rapid expulsion in order to prevent secondary haemorrhage.


Dosage & Administration:

Linda-S should be given by intravenous infusion under adequate control, 1-5 IU added to 500 ml infusion fluid. The administration started at 1 mU (1 mU= 0.001 IU) per minute. According to the effect obtained the doage can be doubled every 30-45 minutes until the uterus threshold has been attained.  A further increase will then usually provide optimal activity. The threshold is generally below 10 mU per minute.

N.B.: Intramuscular administration of Linda-S may lead to irregular response and symptoms of overdosage (see: overdosage). If intramuscular administration is nevertheless unavoidable, dosage should not exceed 0.5- 1 IU per injection.

Intramuscular injection of 2-5 IU, or as intravenous infusion in an adequate dosage.

Intramuscular injection of 2 IU.

intramuscular injection of 2-5 IU every 30-60 minutes or as intravenous infusion in an adequate dosage.


Contraindications:
  • Cephalo-pelvic disproportion.
  • Abnormal position of the child or abnormal position of the skull.
  • Overdistention of the inferior segment of the uterus.
  • Severe toxaemia.
  • Hypertonic uterine dysfunction.
  • Foetal distress, where delivery is not imminent (uterinecontractions may increase hypoxia).
  • Cord presentation and prolapse.
  • Total placenta previa.
  • Vasa praevia.

Warning & Precautions:
  • Since uterine sensitivity to oxytocin may vary widely. Linda-S® should be used with care. The smallest effective dose must be determined for each patient and then utilized to initiate labour.
  • Linda-S® should only be used when adequate medical supervision is provided. Foetal heart rate and maternal blood pressure should be determined.
  • Linda-s® should be used with care if scars of the uterus and of the cervix uteri exist.


Storage Conditions:

Store between 2° - 8° C, frost free & dry place. Keep away from light and out of the reach of children.


Commercial Pack:

Linda-s® each box contains: 10 x 1 ml ampoules in Alu-PVC blister strip.

Linda-S DS® each box contains: 20 x 1 ml ampoules in Alu-PVC blister strip.